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According to the experimental data HKI preferentially binds
2022-05-30
According to the experimental data, HKI preferentially binds to the mitochondrial inter-membrane contact sites formed by ANT and VDAC [[5], [6], [7],27], mainly via the VDAC1 isoform [7,8]. These electrogenic contact sites allow application of a part of IMP to MOM by transferring phosphoryl groups f
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Since we found miR b
2022-05-30
Since we found miR-15b-5p to be differentially expressed along the porcine intestine in 31 day old piglets in a former study [10], the entire miRNA family was analyzed in terms of interaction with potential target-genes. In silico analysis predicted miR-15 family members to target the hedgehog signa
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br Background To treat chronic HCV genotype GT infected
2022-05-30
Background To treat chronic HCV genotype (GT) 1-infected patients, telaprevir (TLP) or boceprevir (BOC), first generation protease inhibitors (PIs), were used in combination with pegylated-interferon (PEG-IFN) and ribavirin (RBV) triple therapy [1], [2]. The main weaknesses of the first-generatio
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When analyzing HIV AIDS patients in S
2022-05-30
When analyzing HIV/AIDS patients in São Paulo, we detected an association between HIV/HTLV-1/2 infection in black/pardo-colored individuals (OR 2.21, 95% CI 1.21–4.03). However, the majority of serum samples were from patients attending specialized services for hepatitis, other than HIV/AIDS or HTLV
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Although it has been observed in numerous studies and by
2022-05-30
Although it has been observed in numerous studies and by many investigators that intraplatelet cGMP elevation results in platelet inhibition, there are a few papers which proposed a platelet stimulatory role for cGMP when elevated in response to NO donors or PDE5 inhibitors in mouse and human platel
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br Materials and methods br Results br Discussion Recently w
2022-05-30
Materials and methods Results Discussion Recently, we characterized the interaction of the PH domains of various Lbc family RhoGEFs with the activated small GTPase, RhoA, and demonstrated that this could serve as a positive feedback mechanism for robust activation of RhoA (Medina et al., 20
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br Materials and methods br Results
2022-05-30
Materials and methods Results Discussion Nervous system disease is an important signal of AIDS deterioration (Rosca et al., 2012, Yilmaz et al., 2012). It is possible that HIV crosses the blood a66 mg barrier or blood cerebrospinal fluid barrier into the central nervous system freely or vi
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Despite the potential promise of both
2022-05-27
Despite the potential promise of both of these peptides, such compounds are still susceptible to efficient renal filtration (Emmanouel et al., 1978, Holst, 1991, Deacon et al., 1996). However, numerous studies have demonstrated that fatty E-4031 dervatisation of related regulatory peptides results i
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PD PD L signaling is critical for the
2022-05-27
PD-1/PD-L1 signaling is critical for the induction of exhausted CD8+ T Caspase-6, human recombinant protein mg during the tumor immune response (Barber et al., 2006; Wherry et al., 2007; Wherry and Kurachi,2015; Pauken and Wherry, 2015), but the relationship between PD-1/PD-L1 signaling and Fas/Fas
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br Ethical standards br Conflicts of interest br Funding Thi
2022-05-27
Ethical standards Conflicts of interest Funding This study was funded by the National Natural Science Foundation of China (grant numbers 81560146, 81660148 and 81760151), Gansu Province health industry research project (grant number GSWSKY-2015-10) and Lanzhou Chengguan District Science and
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We found the FAAH CC genotype only
2022-05-27
We found the FAAH CC genotype only confers risk for anxiety if the CRFR1 minor allele combination is also present. Additionally, the FAAH AA/AC genotype was riskier than the CC if the three CRFR1 minor PD184352 were not present. This result is somewhat contrary to our prediction as we hypothesized
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br Characterization of quantal exocytosis by amperometry A s
2022-05-27
Characterization of quantal exocytosis by amperometry A secretory vesicle experiences four phases during exocytosis: (i) cargo packaging & translocation, (ii) vesicle docking & priming; (iii) fusion pore formation; (iv) fusion pore expansion and cargo secretion (Fig. 1a). The release of monoamine
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Hyperhomocysteinemia HHcy is a clinical condition characteri
2022-05-27
Hyperhomocysteinemia (HHcy) is a clinical condition characterized by increased levels of plasma homocysteine (Hcy) and a well-known risk factor for CVDs. Hcy is a sulfur-containing non-protein amino 17-DMAG formed during the intracellular conversion of methionine to cysteine. Previous study demonst
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In autoimmune diseases lymphocytes penetrate
2022-05-27
In autoimmune diseases, lymphocytes penetrate into the inflammatory lesions of tissues, where it is prominently hypoxic or even anoxic, and utilize glycolysis for an energy supply after activation or under hypoxia (Sitkovsky and Lukashev, 2005; Palazon et al., 2014), which is modulated by the oxygen
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SID 26681509 br Acknowledgements br Introduction Pregnancy b
2022-05-27
Acknowledgements Introduction Pregnancy brings forth significant metabolic reprogramming that induces a number of metabolic changes to ensure that the nutrient requirements of the mother and fetus are met [[1], [2], [3]]. These adaptations change radically over the period of pregnancy dependin
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