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Meanwhile a myriad of studies using tissue and
2022-01-26
Meanwhile a myriad of studies using tissue- and cell type-specific deletion of GPX4 have provided evidence that various tissues/cells, such as distinct neuronal cell populations including glutamatergic neurons of the forebrain [24], Purkinje cells of the cerebellum [74] and motor neurons [75], photo
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We have expanded these studies by doing
2022-01-26
We have expanded these studies by doing EEG recording in the ET-1 model. Using this technique, we demonstrated that activation of either the ETA Cy7 NHS ester mg or the ETB receptor induces electrical seizures. ET-1 induced electrical seizures occurred in the presence of either the ETA receptor ant
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br Acknowledgments We thank Prof Alexander
2022-01-26
Acknowledgments We thank Prof. Alexander D. Johnson and Suzanne M. Noble for kindly providing SN strains. This work was supported by Chinese National Natural Science Foundation Grants 31370105 and 31300057, and Shanghai STCSM Grant 12JC1409300. Introduction Organisms modulate gene expression
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Under increased drug pressure more protease variants with mo
2022-01-26
Under increased drug pressure, more protease variants with more than one substitution will likely become clinically relevant. The accumulation of additional substitutions can allow RAS variants to emerge that alone are not viable, but in combination can rescue the viral fitness. We previously demons
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Beckman Coulter s DxN VERIS Molecular Diagnostics System DxN
2022-01-26
Beckman Coulter’s DxN VERIS Molecular Diagnostics System (DxN VERIS System) is a fully automated system for the quantitative analysis of molecular targets, integrating sample introduction, nucleic Oligomycin Complex extraction, reaction set-up, real-time PCR amplification and detection using TaqMan
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br Conclusion br Disclosure of interest br Acknowledgement b
2022-01-26
Conclusion Disclosure of interest Acknowledgement Introduction Vitamin B6 has long been recognized as a cofactor for many enzymes, especially those involved in amino Safingol metabolism. Apart from its role as coenzyme, recent studies are unveiling a new role of vitamin B6 as a chemoprev
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Since KYNA concentrations are increased by aerobic exercise
2022-01-26
Since KYNA concentrations are increased by aerobic exercise training, we have investigated if it plays a role in peripheral tissue metabolism. Here we show that KYNA regulates adipose tissue energy homeostasis through activation of Gpr35. Activation of this network stimulates the expression of lipid
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Experiments conducted on the human
2022-01-25
Experiments conducted on the human parasite Leishmania major has shown that specific parasitic antigens are involved in steering the immune responses to “protective” as opposed to “disease” state (Reiner et al., 1993; Reiner and Locksley, 1995; and Sjölander et al., 1998) and that antigenic composit
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Analogous to all GPCRs the GLP R transduces signals from
2022-01-25
Analogous to all GPCRs, the GLP-1R transduces signals from the outside of the cell to the inside by allosterically converting a ligand-binding event to activation of intracellular effectors. The GLP-1R couples to several intracellular effectors and this pleiotropic coupling is physiologically releva
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In contrast with the above results in our
2022-01-25
In 4 methylumbelliferone with the above results, in our GC model system, FPR1-, but not FPR2-knockout, enhanced tumour formation. However, it should be noted that the prominent role of mFPR2 with respect to mFPR1 in the mouse colon might be due to the significantly higher expression of mFPR2 than m
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With LML methyl oxo dihydropyridazin yl piperidin yl cyclobu
2022-01-25
With LML-134 (1-(1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)piperidin-4-yl 4-cyclobutylpiperazine-1-carboxylate) containing drug-likeness properties (MW 375.47, five HBA, and MLogP 1.88), Novartis presents an additional drug-candidate to treat excessive sleepiness. A phase I clinical study was perform
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br Pharmacological anti aging approaches and the
2022-01-25
Pharmacological anti-aging approaches and the Hippo pathway Aging and age-related pathologies are the main causes of disabilities and death. As Magalhañes and colleagues suggest, the challenges of developing anti-aging pharmacological therapies may, in part, be due to the complexity of aging mole
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Ultimately the change of maturation ratio of the Leydig
2022-01-25
Ultimately, the change of maturation ratio of the Leydig cell caused reducing of INSL3 expression undoubtedly. INSL3 (insulin-like 3) is a hormone produced mainly in gonadal tissues. It was discovered to participate in development of urogenital tract. The mutations of this gene is one cause of crypt
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When analyzing HIV AIDS patients in S o Paulo we
2022-01-25
When analyzing HIV/AIDS patients in São Paulo, we detected an association between HIV/HTLV-1/2 infection in black/pardo-colored individuals (OR 2.21, 95% CI 1.21–4.03). However, the majority of serum samples were from patients attending specialized services for hepatitis, other than HIV/AIDS or HTLV
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br Conclusion B esterases and reproductive parameters can be
2022-01-25
Conclusion B-esterases and reproductive parameters can be used as effect biomarkers of the aquatic contamination with chlorpyrifos. In P. corneus exposed for 14 days to the insecticide, the carboxylesterases determined with p-NFB proved to be the most sensitive biomarker. However, exposure to env
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