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The diseases of ocular surface and the
2021-12-23
The diseases of ocular surface and the cornea are very common in ophthalmological practice and as a result there is a continuous, need for novel therapeutic options. Here, we demonstrated a corneal distribution of GPR35, a potential molecular target for new drugs (; ). The search for the expression
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br Introduction Adipose tissue AT in addition to its functio
2021-12-23
Introduction Adipose tissue (AT), in addition to its function as protein phosphatase inhibitor storage, is an important endocrine organ and it secretes adipokines (Ahima, 2006). Adipose tissue is related to different physiological processes such as energy metabolism, insulin sensitivity, and inf
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To investigate if such an effect is observed in native
2021-12-23
To investigate if such an effect is observed in native GlyT1, we introduced S605D and S605A mutations into GlyT1 and transfected these DNA constructs into N2a cells. For an internal control of calpain cleavage, we also introduced the first 100 amino-acids of the rat GlyT2N terminus upstream of the m
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br Material and methods br Result
2021-12-23
Material and methods Result Discussion The female with well-differentiated endometrial cancer, especially those in the reproductive age have a strong desire to preserve fertility. Therefore, conservative medical treatment with progestin is widely used in the clinic. However, up to 30% of pa
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br Results br Discussion br Materials and Methods br
2021-12-23
Results Discussion Materials and Methods Introduction Deoxyribonucleic kinase inhibitors (DNA) is among the most important biopolymers in living organisms alongside carbohydrates and proteins. DNA is a linear polymer consisting of four types of nucleobases, deoxyribose, and phosphate. Th
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Molecular dynamics studies have proved an
2021-12-23
Molecular dynamics studies have proved an effective means of characterising transition state pathways between the inward- and outward-facing states, and providing the relative propensity for each state. For example, long-timescale simulations of the membrane-embedded LeuT dimer, totalling ∼21 μs, ha
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A number of experimental data declare a tight
2021-12-23
A number of experimental data declare a tight interdependence between the pathological changes of glutamate transport in 235 6 and consequent alterations in glutamate transport and activity/expression of glutamate metabolizing enzymes in platelets (Aliprandi et al., 2005, Behari and Shrivastava, 201
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Repaglinide GCK MODY is the most
2021-12-23
GCK-MODY is the most common form of MODY diabetes in many populations (Chevre et al., 1998; Massa et al., 2001; Barrio et al., 2002; Estalella et al., 2007; Pruhova et al., 2010; Capuano et al., 2012; Giuffrida et al., 2017). However, data about GCK-MODY among North African populations are very rare
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Deregulation of HH signaling pathway in epidermal
2021-12-23
Deregulation of HH signaling pathway in epidermal keratinocytes is a primary event leading to the formation of BCC (see above). Overexpression of SHH in HaCaT keratinocytes grown in organotypic cultures induces a basal cell phenotype and increases invasiveness. This behavior is linked to increased E
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br Materials and method http www apexbt com media diy
2021-12-23
Materials and methods Results Discussion This study provide for the first time a report on GALP in fish, providing new information towards the distribution and functional characterization of the galaninergic system in these vertebrates. Our studies show the detailed neuroanatomical distribu
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AZ505 ditrifluoroacetate We found that silymarin induced
2021-12-22
We found that silymarin induced more improvement of renal functions compared to Rvs. Our results were in agreement with previous studies. The effect of silymarin has been tested in alloxan-induced diabetes mellitus models in rats. Alloxan produces reactive oxygen species which injure renal tissue. S
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br Materials and methods br
2021-12-22
Materials and methods Results To examine the apoptosis in FLS in vitro, we measured the number of Medroxyprogesterone acetate in early apoptosis (Annexin V+, 7-AAD−) and late apoptosis/necrosis (Annexin V+, 7-AAD+) using flow cytometry after incubation with or without stimulating Fas antibody
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In general FPSs require Mg or Mn as a
2021-12-22
In general, FPSs require Mg2+ or Mn2+ as a cofactor for GPP and FPP synthesis. Co2+ also acts as a cofactor in EuFPSs, as in the case for PcFPS and Abies grandis FPS [29], [44]. Co2+ enhanced the activity of EuFPS1 more than the activity of EuFPS2: Mg2+, Mn2+ and Co2+ had approximately the same effe
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In order to establish proper folding and enzymatic activity
2021-12-22
In order to establish proper folding and enzymatic activity, G9a and GLP methyltransferases each contain four structural zinc ions. Both CCCP receptor contain two distinguishable types of zinc fingers; three Zn(II) ions are chelated in a triangular cluster by 9 cysteines (b, top left), whereas one
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PRT 4165 ANT located in the IMM mediates the exchange of
2021-12-22
ANT, located in the IMM, mediates the exchange of ATP/ADP between the mitochondrial matrix and the intermembrane space (IMS) (Brand et al., 2005; Palmieri and Pierri, 2010). Of the 4 known isoforms, ANT1 is the dominant isoform in the heart (Palmieri and Pierri, 2010). Under physiological conditions
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