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br Differences among flavivirus vaccines and implications fo
2021-12-17
Differences among flavivirus vaccines and implications for CD4 T cell immunity There are currently three classes of flavivirus vaccines in use – live-attenuated virus (for immunoprophylaxis against YF and JE), whole inactivated virus vaccines (JE, TBE) and chimeric vaccines (JE, DEN). The chimeri
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In conclusion we demonstrated that the
2021-12-17
In conclusion, we demonstrated that the atypical high-basal activity of the mGlu3 92 8 results mostly from its activation by low ambient glutamate concentrations. This is due to a unique interaction network located in the extracellular domain of the mGlu3 receptor. This network acts as “Cl− lock” th
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During the course of our optimization of the diarylsulfonami
2021-12-16
During the course of our optimization of the diarylsulfonamide chemotype as FFA4 agonists, we identified xanthene as a potent and selective antagonist of FFA4 (). Xanthene was able to block the agonist induced intracellular Ca response elicited by both linoleic Riboflavin receptor and compound i
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br Methods and materials br Results
2021-12-16
Methods and materials Results Discussion In this study we demonstrate that CF epithelial Milnacipran HCl exhibit features of apoptosis in their basal, unstimulated state including increased caspase (-3 and -8) activation compared to non-CF epithelial cells. Analysis of factors responsible f
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Although some PAHs that are human carcinogens
2021-12-16
Although some PAHs that are human carcinogens have been found in the sugarcane soot (Zamperlini et al., 1997), there are no data about cancer incidence among sugarcane workers. To the best of our knowledge, this is the first report of an evaluation of internal exposure, comparing the harvesting (whe
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br GSNOR activity and functions The identification of the en
2021-12-16
GSNOR activity and functions The identification of the enzyme responsible for GSNO decomposition dates back to 1998, when Jensen and colleagues described an NAD(P)H-dependent GSNO catabolizing activity in cytosolic fractions obtained from rat liver [16]. Upon purification, they identified this en
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Even with all of the
2021-12-16
Even with all of the subunits present, the complex must also be correctly assembled for the enzyme to function properly. The complex is first assembled in the endoplasmic reticulum, with NCT and APH-1 binding together. They form the initial scaffold, so full-length PS can attach itself, and finally
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The coenzyme S adenosylmethionine SAM binding pocket of
2021-12-15
The coenzyme S-adenosylmethionine (SAM)-binding pocket of Set7 is connected to the histone-tail binding groove by a conserved lysine-channel, similarly observed in vSET (Figures 2D and S3). The Set7 SAM-binding pocket is negatively charged as observed in other known HMTase structures. However, the b
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Corollary and Lemma Finally Corollary and
2021-12-15
(Corollary 3 and Lemma 9). Finally, Corollary 5 and Lemma 10 show that if then the support of is wide enough and so must contain the points of maximum of the attached. However, the support of is too narrow and so does not contain the points of maximum of the remote. Hence, the remote has at most
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A few research articles described that PLGA could alone
2021-12-15
A few research articles described that PLGA could alone improve physiological activities in certain illnesses by exerting therapeutic effects. These reported therapeutic activities of PLGA can be appended to the hydrolysis products of PLGA lactate, glycolate, and H+. We will recapitulate their respe
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Reports of hyperlocomotion after administration of
2021-12-15
Reports of hyperlocomotion after administration of ALX-5407 [27] coupled with the lack of hyperlocomotion after administration of SSR504734, a non-sarcosine, long-residence time, competitive inhibitor [19], suggested that the GlyT1 inhibitor chemotype may impact OP. Furthermore, a compound with a co
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br Spatial working memory is GluR A dependent
2021-12-15
Spatial working memory is GluR-A-dependent The radial maze task also allowed us to study hippocampus-dependent spatial working memory. On spatial working memory tasks, the correct spatial response that the animal must make varies from trial to trial and is dependent on some conditional, trial-spe
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Importantly the levels of the pro inflammatory
2021-12-15
Importantly, the levels of the pro-inflammatory cytokines TNF-α and IL-1β and Nf-κB, a key transcription factor in chronic inflammatory responses that is activated by pro-inflammatory cytokines, were also reduced by the drugs, confirming our previous results that demonstrated anti-inflammatory effec
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Further we examined the degradation of Cx
2021-12-15
Further, we examined the degradation of Cx43. Autophagy and the proteasome system have previously been implicated in Cx43 degradation (Falk et al., 2014). DEX inhibited communication between Entinostat by promoting the degradation of Cx43 through autophagy in osteocytes (Gao et al., 2016). In our ex
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br Material and methods br Results and discussion br Discuss
2021-12-15
Material and methods Results and discussion Discussion It is well established that the guanosine-rich DNA sequences within telomeric DNA repeats, and in the promoter regions of a number of oncogenes or proto-oncogenes such as c-myc [20,23], VEGF [28,48,49] and Bcl-2 [21,50], can readily ass
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