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After incorporation of random nucleotides by TdT during
2020-12-16
After incorporation of random Cy3-UTP by TdT during heavy-chain rearrangements, both TdT and pol λ may perform in trans polymerase activity (in unknown proportions), whereas synthesis of the complementary strand can only be achieved by pol λ using its gap-filling activity, which TdT lacks because o
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br Introduction DNA ligation is
2020-12-16
Introduction DNA ligation is required during DNA replication and to complete almost all DNA repair events. In human cells, the DNA ligases encoded by three LIG genes are responsible for joining interruptions in the phosphodiester backbone [1]. These enzymes have distinct but overlapping functions
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According to our results germination of
2020-12-16
According to our results, germination of transgene dgks lines didn’t differ under optimal conditions and 50 mM NaCl, while 100 mM NaCl slightly affected germination rates of dgk mutants. Exogenous application of EBL even diminished the effect of 100 mM NaCl on dgk mutants. The critical effect on ger
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Keeping the cofactor content oligomeric state subcellular lo
2020-12-16
Keeping the cofactor content, oligomeric state, subcellular localization, and membrane association in view, DHODH has been broadly divided into two classes, class 1 and class 2 [26], [27]. In many species it is present to either cytoplasm (Class 1) or to the inner mitochondrial membrane (or plasma m
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br Results br Discussion Prostate cancer dissemination and s
2020-12-16
Results Discussion Prostate cancer dissemination and skeletal metastases represent major therapeutic challenges. Once the skeletal metastasis occurs, the incurable patient could just be symptomatically treated to alleviate the pain. Therefore it is of great necessity to disclose the molecular
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In these studies the inflammatory cytokine IL
2020-12-16
In these studies, the inflammatory cytokine IL-8 was demonstrated as one of the responsible molecules induced by CysLTs via activating CysLT2 receptors. IL-8 is synthesized in and released from mononuclear cells, macrophages, fibroblasts and airway epithelial cells, and it promotes inflammation as a
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HEK cells stably transfected with CysLT were stimulated with
2020-12-16
HEK-293 lysophospholipid receptor stably transfected with CysLT1 were stimulated with LTD and internalization was studied by confocal microscopy, FACS or cell-surface ELISA. Cells were co-transfected with wildtype and dominant negative (DN) mutants of arrestin and dynamin. Clathrin-mediated endocy
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Each of the CYP enzymes alluded
2020-12-16
Each of the CYP450 enzymes alluded to above are highly selective catalysts, in that, the three aryl coupling reactions en route the biosynthesis of 1 are catalyzed by three different CYP450 enzymes in a sequential manner (Fig. 1). In sharp hiv fusion inhibitors is the recently described marine bact
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Interestingly ASV infusion in the dRN of saline
2020-12-16
Interestingly, ASV-30 infusion in the dRN of saline pre-treated rats had no effect on anxiety-like behaviors. This result may be due to the saline pre-treated group exhibiting relatively low levels of anxiety-like behaviors (when compared to saline pre-treated rat of the first experiment that were n
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Conversely to the reduction in restraint evoked
2020-12-16
Conversely to the reduction in restraint-evoked HR increase following the blockade of CRF receptors, Nijsen et al. [28] demonstrated that BNST treatment with a nonselective CRF PHA-848125 antagonist enhanced the tachycardia evoked by contextual fear conditioning. Taken together, these results indic
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Additionally of outmost important is the
2020-12-16
Additionally, of outmost important is the location of the different CpG islands in relation to the transcription starting site (TSS) of the promoter as well as their interaction with transcription activators or repressors. It has been shown that methylation at the downstream region of the TSS in the
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We also found a significantly inverse
2020-12-16
We also found a significantly inverse correlation of OPRM1 CpG2-4 methylation level with HDL-C in Han male controls. Lipids are known to involve the inflammation pathway, Aβ formation and stability of neuron, whereby their abnormalities have been shown to increase the risk of AD [39], [40], [41]. HD
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Data presented herein suggest that competent IL
2020-12-16
Data presented herein suggest that competent IL-18BP production in epithelial Saxagliptin is implemented by epigenetic means based on demethylation of a single CpG site at −45 bp/−44 bp (CpG2) of the human IL18BP promoter. In contrast, retarded IL-18BP production in monocytic cells associates with C
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There are studies that evaluated the
2020-12-15
There are studies that evaluated the stability of CMV DNA over different periods of time. A study that evaluated stability of EDTA plasma samples stored over a 21-day period at 4 °C found no significant change in the viral loads or any trend of continued DNA degradation [9]. Another study did not fi
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nmda Previous studies have documented that SCFAs may
2020-12-15
Previous studies have documented that SCFAs may elicit effects on lipid metabolism via de novo synthesis and transport. Acetate is not only used as an energy source, but is also constituted as a substrate for the cholesterol synthesis in the liver through acetyl-CoA, thus affecting plasma cholestero
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