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AMPK is a master regulator
2020-11-09
AMPK is a master regulator of metabolic homeostasis, its broad spectrum of metabolic activities makes it an attractive target for treatment of metabolic and related disorders including Diabetes and Obesity (Madhavi et al., 2018). It controls lipid metabolism through its target genes PPAR-γ, C/EBP-α
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Introduction Numerous professional governmental and
2020-11-09
Introduction Numerous professional, governmental, and media sources report a strong demand for and even a scarcity of new entrants to the fields of professional accounting and auditing. Furthermore, reports emphasize expectations of continuing high demand in the future (AICPA, 2015, Manpower Group,
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Unlike previous studies examining COMT genotyping
2020-11-09
Unlike previous studies examining COMT genotyping in healthy controls seeking to explain impulsive behaviors, this study sought to examine COMT genotypes in a large sample of individuals with varying levels of gambling behavior to determine whether COMT orexin receptor was associated with differenc
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Our module is designed to allow in process measurement of
2020-11-09
Our module is designed to allow in-process measurement of [C]-tracer molar activity (MA, GBq/μmol at EOB) using a CP 154526 sale detector with a UV detector at the outlet of the HPLC-portion of the system. In the HPLC chromatogram, peak analysis of the chromatographic data utilized PeakSimple softw
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Other studies have investigated the role of HDAC inhibitors
2020-11-09
Other studies have investigated the role of HDAC inhibitors in particular signaling pathways mediated by EWS–FLI1 (Matsumoto et al., 2001). A recent investigation, showed a physical association of EWS–FLI1 and HDAC1 that helps mediate a disruption in the p53 activation of downstream targets (Li et a
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An Emerging Role for the EphrinB EphB RASA Signaling Axis
2020-11-09
An Emerging Role for the EphrinB2-EphB4-RASA1 Signaling Axis in Human Congenital Cerebrovascular Disorders Normal vascular development includes de novo blood vessel formation from endothelial cells (ECs) (vasculogenesis) 1, 2, expansion of the network through vessel sprouting, splitting, and remode
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PGE EP activation has been found to
2020-11-09
PGE2-EP4 activation has been found to attenuate the activation of microglia and to prevent lipid peroxidation and pro-inflammatory gene expression in a murine model of lipopolysaccharide (LPS)-induced melatonin receptor agonist inflammation [15]. Moreover, PGE2/EP4 signaling has elicited a protecti
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MI has been detected in wastewater at concentrations of g
2020-11-09
3MI has been detected in wastewater at concentrations of 640–700 μg L−1 (Hwang et al., 1995) and up to 20 mg L−1 in decaying algal water environments (Peller et al., 2014). It is likely that 3MI accumulation in fish might be due to the degradation of endogenous amino acids. The presence of this che
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Ubiquitin activating enzyme activates ubiquitin by a three
2020-11-09
Ubiquitin-activating enzyme activates ubiquitin by a three-step process with ATP as a cofactor (Chen et al., 2011, Haas and Rose, 1982, Haas et al., 1982). We demonstrated that ATP is required for mRFP-Ub–E1 formation under non-reducing conditions (Fig. 2A). A time course of radioactive ATP product
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In summary our data show a
2020-11-06
In summary, our data show a novel mechanism: CPD-mediated autoprocessing of C difficile toxins regulates their proinflammatory activities. Thus, our study provides a new understanding of the molecular mechanisms of the pathogenesis of C difficile toxins and insights into designing new therapeutics a
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br Acknowledgments br Introduction Cysteinyl leukotrienes Cy
2020-11-06
Acknowledgments Introduction Cysteinyl leukotrienes (CysLTs), LTC4, LTD4 and LTE4, are 5-lipoxygenase pathway metabolites of arachidonic LX-1031 and deeply involved in bronchial asthma via activation of CysLT1 receptors [1], [2]. Specific CysLT1 receptor antagonists, including pranlukast [3],
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br User knowledge representation Various
2020-11-06
User knowledge representation Various representation approaches of user interests and preferences are proposed. In this work, we advocate a multidimensional semantic approach based on Bouzghoub et al. meta-model (Bouzeghoub and Kostadinov, 2005), depicted in Fig. 6, to model the user profile. The
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Iris domestica L Goldblatt Mabb syn Belamcanda chinensis L
2020-11-06
Iris domestica (L.) Goldblatt & Mabb. (syn. Belamcanda chinensis L.) DC. (Iridaceae) occurs naturally in South and East Asia. Despite the fact that former monotypic genus Belamcanda has been included in the extended genus Iris, this classification has been questioned (Wilson, 2011; Mavrodiev et al.,
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Bmp products such as Fig are persistent pollutants that accu
2020-11-06
Bmp7 products, such as 7–9 (Fig. 2), are persistent pollutants that accumulate in the marine environment and can potentially be transferred to the human population via our trophic connections to the oceans (Wan et al., 2009). In addition to potentially addressing the mechanistic curiosities describe
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ERR induces the expression of P c in
2020-11-05
ERRγ induces the expression of P450c17 in MA-10 cells and in mouse primary Leydig cells (Fig. 2). Deletion mutant analysis of putative ERRγ-binding sites in the P450c17 promoter suggested that only the proximal third site located between −269 bp and −136 bp within the P450c17 promoter is functional
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