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In addition to peroxyl radicals the most found
2023-09-19
In addition to peroxyl radicals, the most found radical forms in biological systems, some of assays took into account other free radicals such as superoxide anion, hydroxyl, hydrogen peroxide, singlet oxygen and peroxynitrite. ORAC procedure was also modified using different radical sources such as
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Tenatoprazole receptor br Antioxidant polymers conjugates Na
2023-09-19
Antioxidant-polymers conjugates Natural antioxidants are usually used as a substitute for synthetics but some degradation phenomena could influence their applications. For example, ascorbic Tenatoprazole receptor as a natural antioxidant undergoes yellowish coloration as a result of oxidation [2
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Overexpression of AR in a transgenic mouse model
2023-09-18
Overexpression of AR in a transgenic mouse model leads to a capsular cataract phenotype involving proliferation and formation of a fibrotic plaque of cells reminiscent of cells at the posterior ephrin receptor in PCO [17]. To investigate the molecular mechanism that could link AR expression to this
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To investigate the potential link between G
2023-09-18
To investigate the potential link between Gβγ and MT assembly in vivo, cultured NIH3T3 and PC12 cells were used. The role of Gβγ in MT assembly was demonstrated using nocodazole, a MT depolymerizing drug [14]. We found that Gβγ was preferentially bound to MTs in NIH3T3 and PC12 cells and treatment w
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The results also showed that the A receptor http www
2023-09-18
The results also showed that the A3 receptor agonist increased the phosphorylated levels of Akt, leading to activation of the PI3K/Akt pathway. A3 K02288 stimulation has protective effects against RGC death following ischemia-reperfusion, glutamate toxicity, and optic nerve transection models (Galv
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Beside activation of adenosine receptors A a A
2023-09-18
Beside activation of adenosine receptors (A2a.1, A2a.2, A2b) by FSK treatment, the expression of adenosine receptors was also upregulated, when embryos were exposed to inhibitors (SU5416 and DAPT) alone and also combined with FSK. Our data imply that adenosine receptor was associated with a positive
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Earlier studies revealed an interaction between HSP and ACK
2023-09-18
Earlier studies revealed an interaction between HSP90β and ACK1 [15]. In the proteomic approach, we show that ACK1 associates with HSP90α and HSP90β. Additionally, we confirm the existence of a HSP90-ACK1 complex with co-IP experiments. We further analysed whether an inhibition of HSP90 affected the
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br Funding br Introduction l Dihydroxyphenylalanine l
2023-09-18
Funding Introduction l-3,4-Dihydroxyphenylalanine (l-DOPA) is the gold-standard treatment for the motor symptoms of Parkinson's disease (PD); however, its chronic use induces severe motor complications that eventually limit its long-term efficacy (Bastide et al., 2015). The most disabling side
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The earliest appearance of tumors occurred at months and the
2023-09-18
The earliest appearance of tumors occurred at 12 months and the latest at 24 months, with an average onset at 18 months (Fig. 1B). This would be roughly equivalent to cancer presenting in a patient between 60 and 70 years of age. In transgenic animals, autotaxin MK-2206 was relatively increased in
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Another topic for research will be
2023-09-18
Another topic for research will be the combination of other cytotoxic agents with Aurora kinase inhibitors. Particularly interesting might be the combination of Aurora kinase inhibitors and agents that depend on the spindle checkpoint for their activity, such as the taxanes, given the importance of
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The relative stereochemistry of both the major
2023-09-18
The relative stereochemistry of both the major and minor diastereoisomer of (±)-2-(hydroxymethyl)blebbistatin (±)- (and thus (±)-2-(allyloxymethyl)blebbistatin (±)-) was determined with 1D-NOESY experiments (), as crystallization efforts failed. These experiments revealed an interaction between H an
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Furthermore because most of foods and beverages
2023-09-18
Furthermore, because most of foods and beverages have been consumed after processing, researchers have focused on the effects of processing (e.g. blanching, cooking, drying, cooling, freezing, high-pressure treatment, pulsed electric field) on total antioxidant capacity of foods. In general, there w
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Serum concentrations of APP and
2023-09-18
Serum concentrations of APP and antioxidants of the 10 queens with pyometra before surgery (T0), at day two (T1) and at day 10 (T2) after ovariohysterectomy are presented in Fig. 1. Concentrations of SAA and Hp were significantly lower (P Discussion Acute phase protein responses were already desc
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Introduction Enzymatic browning degrades quality
2023-09-18
Introduction Enzymatic browning degrades quality, safety, and nutritional values of various fruits or vegetable products. For example, the color of apple or potato is generally yellowish, representing freshness. However, they are extremely susceptible to enzymatic browning because of abundant polyp
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While there is much in vivo work on prion
2023-09-16
While there is much in vivo work on prion-like Aβ, it has not been shown that one can induce inclusions of Aβ in cultured cells as has been shown for tau and α-synuclein. One reason is practical; Aβ is a low molecular weight metabolite cleaved from within the larger amyloid precursor protein (APP) a
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