• Here we used chemogenetic modulation of

  2022-04-08

  

  Here, we used chemogenetic modulation of MBH GHSR neurons to address the role of the endogenous ghrelin system in the normal, hyperphagic response to a short-term fast. Studies demonstrating the requirement of an intact ghrelin-GHSR system for the rebound food intake following fasting have been inco

• Ghrelin is mostly known for its

  2022-04-08

  

  Ghrelin is mostly known for its orexigenic properties, whereas the role of DAG on feeding is controversial with studies claiming an orexigenic, anorexigenic or no effect (Inhoff et al, 2009, Toshinai et al, 2006). One of these studies was that of Toshinai and colleagues, who found a link between the

• br Central control of GI ghrelin secretion

  2022-04-08

  

  Central control of GI ghrelin secretion The CNS communicates with the GI tract through the vagus nerve originating in the DMV and sympathetic spinal afferents emanating from the thoracic spinal chord (Bray, 2000). The cells that secrete peripheral ghrelin are under direct control of these two pat

• nevertheless Studies have shown that coexpression of the

  2022-04-07

  

  Studies have shown that coexpression of the HAC1 gene in P. pastoris improved the nevertheless level of foreign proteins [24,25]. By coexpression with PDI and Ero1, the expression level of the coexpressed strains was increased by 60% [26]. In our study, the α-galactosidase gene was coexpressed with

• br Acknowledgements This work was supported under the

  2022-04-07

  

  Acknowledgements This work was supported under the National Natural Science Foundation of China (Grant numbers 31200576, 21472197, 21675162), Beijing Natural Science Foundation (Grant No. 7182189), and Project supported by the Joint Funds of the National Natural Science Foundation of China (Grant

• br FXR FGF in the control of BAs

  2022-04-07

  

  FXR–FGF15/19 in the control of BAs synthesis The nuclear receptor FXR is the master regulator of BAs homeostasis, modulating their synthesis, the full details and uptake [15]. FXR decreases BA de novo hepatic biosynthesis by reducing the expression of CYP7A1. At the canalicular membrane, newly-s

• Ligand selectivity may directly be related to the

  2022-04-07

  

  Ligand selectivity may directly be related to the conformational landscape explored by GPCRs despite that most GPCRs do not require dimerization for ligand recognition (Mary et al., 2012). Monomer FPRs have traditionally been perceived as receptors that can recognize N-formyl peptides and LXA4. This

• Recently Bristol Myers Squibb and

  2022-04-07

  

  Recently, Bristol-Myers Squibb and Merck reported their GPR40 agonist research focused on the modification of α,β-position of phenylpropionic Doxorubicin HCl synthesis derivatives. For example, in recent published patent applications, Bristol-Myers Squibb claimed the pyrrolidine and dihydropyrazole

• br Materials and methods br Results br

  2022-04-07

  

  Materials and methods Results Discussion The distribution of FFA1 and FFA4 expressed in normal tissues is distinguishable. FFA1 is expressed in the restricted organ, such as pancreatic beta Mycophenolic acid [18]. In contrast, FFA4 is highly expressed in the lung, gastrointestinal tract, ad

• The ability of GPX and

  2022-04-07

  

  The ability of GPX4 and other selenoproteins to be selectively induced by ferroptotic stimuli suggests that the stress-induced increase in the transcription of a number of putative, “antioxidant” selenoproteins is an adaptive homeostatic, but insufficient response to prevent cell death in the face o

• br Introduction Atrial fibrillation is the most common

  2022-04-07

  

  Introduction Atrial fibrillation is the most common cardiac arrhythmia (Benjamin et al., 1998). Pulmonary vein (PV) sleeves contain a mixture of working myocardium and potential arrhythmogenic pacemaker adenosine deaminase inhibitor behaving as an ectopic trigger of atrial fibrillation (Haissagu

• br Conflict of interest statement br

  2022-04-07

  

  Conflict of interest statement References and recommended reading Papers of particular interest, published within the period of review, have been highlighted as: Acknowledgements We thank Urann Chan for assistance with the figures. This work was supported in part by National Institutes of

• When studying the potential of HATi for the

  2022-04-07

  

  When studying the potential of HATi for the treatment of inflammatory lung diseases, investigating lung tissue specific effects may be particularly relevant since local administration of small molecule inhibitors in lung tissue is possible and is already applied for inhaled glucocorticoids in the tr

• br Materials and methods br Results br Discussion

  2022-04-07

  

  Materials and methods Results Discussion Type I ECa is associated with estrogen excess, obesity and hormone-receptor positivity. However, the function of ERα on ECa is considered complicated. The expression of ERα is reduced in grade III ECa clinical samples [13]. The high ERα expression is

• The finding of histamine action on

  2022-04-07

  

  The finding of histamine action on ASICs also raises the question about possible action of other histamine receptor ligands. In the present work we selected several compounds and performed electrophysiological testing of their action on recombinant homomeric ASIC1a and ASIC2a. Nα-methylhistamine is

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