• Despite potent biological actions the

  2021-11-04

  

  Despite potent biological actions, the native hormone undergoes degradation by the enzyme dipeptidylpeptidase-IV (DPP-IV) [17] and is rapidly cleared from the bloodstream by renal filtration [18]. One such approach to prolong the biological half-life of GIP is through conjugation with a polyethylene

• Recently multiple receptor agonists have been

  2021-11-04

  

  Recently, multiple receptor agonists have been developed to treat type II diabetes (Finan et al., 2013, Finan et al., 2015). We have tested novel dual GLP-1/GIP receptor agonists that showed good neuroprotective effects that are superior to single GLP-1 analogues (Cao et al., 2016, Jalewa et al., 20

• Next we conducted subgroup analyses with stratification alon

  2021-11-04

  

  Next, we conducted subgroup analyses with stratification along interaction variables, namely the PPARG SNP and fasting NEFA. The study population was thus stratified into high and low NEFA (along the median NEFA, 561 μmol/L), and PPARG minor allele (Ala) carriers. This stratification resulted in 4 s

• br Development of calibrators and controls for DiXaIs

  2021-11-04

  

  Development of calibrators and controls for DiXaIs Method validation and comparison with reference technique (LC:MS) At this stage, anti-Factor Xa bioassays can be established for reliably measuring DiXaI concentrations in plasma, with the available appropriate drug specific calibrators and co

• During the activation of the coagulation

  2021-11-04

  

  During the activation of the coagulation cascade, factor Xa (FXa) forms a complex with activated factor V and calcium Phos-tag Biotin BTL-105 on the surface of platelet membrane (so called prothrombinase complex) and converts prothrombin to thrombin [5], [6]. Selective FXa inhibitors do not directl

• br Discussion Our study found that of MSM from Natal

  2021-11-04

  

  Discussion Our study found that 62.6% of MSM from Natal had been tested for HIV before. This rate was higher than the national average of 37% estimated for the general FK228 in 2011 and the 51.6% found by Brito et al. in MSM from 10 Brazilian cities in 2009. These rates are rather disappointing

• In our study SHH protein overexpression was significantly as

  2021-11-03

  

  In our study, SHH protein overexpression was significantly associated with lymph node metastasis which is in agreement with the study done by Marechal et al. wherein they have reported that SHH is a prognostic biomarker in PDAC and high levels correlate with lymph node metastasis (Maréchal et al., 2

• One of the key epithelium derived factors required

  2021-11-03

  

  One of the key epithelium-derived factors required to maintain immune tolerance in the intestine is Indian Hedgehog (Ihh). Ihh is secreted exclusively by intestinal epithelial cells, and signals in a paracrine manner to the inhibitory receptor Patched1 (Ptch1) on Tranexamic Acid in the mesenchyme.

• HPgV coinfection has been associated with reduced liver dise

  2021-11-03

  

  HPgV coinfection has been associated with reduced liver disease in HPgV/HCV/HIV triply infected patients (Barbosa Ade et al., 2009, Berzsenyi et al., 2007, Berzsenyi et al., 2009, Berzsenyi et al., 2011). It is possible that HCV NS3 protease inhibitors could inhibit HPgV replication diminishing its

• The neurotransmitter histamine plays a key role

  2021-11-03

  

  The neurotransmitter histamine plays a key role in the sleep-wake cycle and in learning and memory. Alterations in micromolar to molar histamine levels are closely connected with central nervous system dysfunction, and are thought to contribute to neurological disorders, including Alzheimer's diseas

• In our substudy patients carrying the

  2021-11-03

  

  In our substudy, patients carrying the Ile/Val or Val/Val genotypes had significantly worse DFS compared to patients carrying the Ile/Ile genotype, after adjustment for potential confounders. Two previous studies examining the association between HER2 Ile655Val polymorphism and trastuzumab response

• In addition to narrowing a

  2021-11-03

  

  In addition to narrowing a wide knowledge gap in Hh developmental biology research, improved understanding of Disp structure and function is likely to also be relevant to cancer. A growing body of evidence supports that Shh facilitates tumor–stroma communication in a range of cancers to influence tu

• It is an open question if these

  2021-11-03

  

  It is an open question if these in vitro findings have implications for the use of sGC activators in the in vivo situation and in patients. Assuming that incorporation in de novo synthesised enzyme occurs during therapy, one might speculate that the duration of drug administration has an influence o

• To characterize the basic functions of

  2021-11-03

  

  To characterize the basic functions of GPR84 in phagocytes, we have utilized the receptor selective antagonist GLPG1205 (a small selective antagonist of GPR84 developed by Galapagos NV [14]) together with ZQ16 (2-(hexylthio) pyrimidine-4,6-diol), a potent GPR84 selective agonist identified in a high

• The HIV genome encodes for a variety of viral proteins

  2021-11-03

  

  The HIV-1 genome encodes for a variety of viral proteins necessary for target cell entry and viral replication. gp120 is an HIV-1 envelope glycoprotein that mediates viral particle entry by binding to cell surface receptor CD4 and co-receptors CXCR4 and/or CCR5 depending on viral tropism. While CXCR

15552 records 544/1037 page Previous Next First page 上5页 541542543544545 下5页 Last page