• Previous studies reported that NE and MHPG are deeply

  2021-05-22

  

  Previous studies reported that NE and MHPG are deeply involved in depression and that NE reuptake inhibitors are approved for use in patients with depression (for review, see [2]). We found increased hippocampal content of NE and MHPG in the CORT-treated CRTH2−/− mice (Fig. 3). In the hippocampus, a

• In this study we observed alterations

  2021-05-22

  

  In this study, we observed alterations in mRNA levels of CRF receptors in the PFCx and Hip during the development of sensitization. In particular, in the Hip both CRF receptors showed significantly increased Tankyrase Inhibitors 49 mg when the sensitization condition was established. Similarly, CRF

• Emi protein consists of an N

  2021-05-21

  

  Emi2 protein consists of an N-terminal regulatory region and a C-terminal functional region. The C-terminal region contains a destruction box (D-box), which likely competes with APC/C substrates (including cyclin B) for APC/C binding, and a zinc-binding region (ZBR), which somehow inhibits APC/C ubi

• As plants can only take up P in an

  2021-05-21

  

  As plants can only take up P in an inorganic orthophosphate form, it was expected that the proportion of orthophosphate P in the OA would be a good indication of the availability of the P in the OA. While the P speciation of the COMP sample could not be determined by deconvolution due to the broadne

• The endothelin receptor type B EDNRB belongs to the family

  2021-05-21

  

  The endothelin receptor type B (EDNRB) belongs to the family of G protein-coupled receptors, which functions as a vital regulatory factor in signal transduction in cells, locating on human chromosome 13q22.3 (Ayala-Valdovinos et al., 2016; Bregar et al., 2018; Morimoto et al., 2018; Widowati et al.,

• Celiac disease occurs in the small intestine due to

  2021-05-21

  

  Celiac disease occurs in the small intestine due to the ingestion of gluten and triggers an immune response by T-cells resulting in tissue remodelling and malnutrition [6]. Earlier studies by many researchers have shown that the prolamins of gluten are the toxic agent for celiac disease, since they

• CYP contributes to the metabolism

  2021-05-21

  

  CYP450 contributes to the metabolism of more than 90% of currently available drugs (Shapiro and Shear, 2002). Currently, CYP1A is the most studied xenobiotic-metabolizing isoform in fish and is often used as a biomarker for early effects of pollutants in aquatic organisms (Havelkova et al., 2007). T

• The Lysine mutant is located in the

  2021-05-21

  

  The Lysine429 mutant is located in the tail region of 5-HT2A, which is predicted to be unstructured. This region has been shown to interact, in vitro, with PSD95 and leads to differences in signaling (Xia et al., 2003). The ASK motif, a component of the tail region, is also important for regulation

• We also performed a correlation analysis independent of anno

  2021-05-21

  

  We also performed a correlation analysis independent of annotated gene sets to identify potentially novel genes that are co-expressed with DHODH. Using the top 100 DHODH co-expressed genes in COAD, LGG, STAD, and PAAD diseases, we identified four common genes across all four diseases (Fig. 9). These

• BMN673 receptor DDR expression is upregulated in the glomeru

  2021-05-21

  

  DDR1 expression is upregulated in the glomeruli and tubules of injured kidneys [7], [8], [19]; however, what role this receptor plays in kidney resident BMN673 receptor is unclear. A plausible hypothesis is that DDR1 might contribute to kidney injury by directly exerting a pro-fibrotic action. In f

• One of the most frequent gene alterations in

  2021-05-21

  

  One of the most frequent gene alterations in MM is methylation of the p15 and p16 genes in the 5′ upstream region. P15 and p16 proteins are Nutlin 3 regulators involved in the inhibition of transition from G1 to S phase. Frequencies of p15 or p16 gene methylation up to 32% and 53%, respectively, h

• Asiaticoside In summary our findings show

  2021-05-21

  

  In summary, our findings show that LPS can activate CysLT2R on microglial Asiaticoside to induce microglial inflammation and microglia-dependent neuronal death. Furthermore, pharmacological inhibition or knocking down of CysLT2R expression protects neurons against neurotoxicity via suppression of L

• Within their range of applicability both approaches

  2021-05-20

  

  Within their range of applicability, both approaches matched the phase boundaries and yields generally to within the measurement error. The approaches matched the phase compositions generally to within 11 wt% or less with the average absolute deviations listed below: One advantage of the proposed a

• In modern science and technology many

  2021-05-20

  

  In modern science and technology, many optimization problems need to be solved in real time, while these classical methods cannot render real-time solutions to these optimization problems, especially large-scale problems. As a new metaheuristic, particle swarm optimization (PSO) [18], [19] has prove

• Apoptosis type I programmed cell death is considered to be

  2021-05-20

  

  Apoptosis, type I programmed cell death, is considered to be involved in the pathogenesis of various liver diseases, such as autoimmune hepatitis [[5], [6], [7], [8], [9], [10]] and hepatocellular carcinoma [11,12]. Apoptosis is activated by a variety of extrinsic or intrinsic pathways factors. Prev

15637 records 645/1043 page Previous Next First page 上5页 641642643644645 下5页 Last page