• br Introduction As a serine proteinase and a

  2020-12-30

  

  Introduction As a serine proteinase and a sub-family of the chymotrypsin-like proteinase, Glutamyl endopeptidase (GE), which is mainly found in Bacillus species, specifically cleaves negatively charged amino Cryptotanshinone residues (Glu/Asp) (Yokoi et al., 2001). Madsen et al. (Madsen & Qvist,

• br Acknowledgments br Multicellular organisms respond rapidl

  2020-12-30

  

  Acknowledgments Multicellular organisms respond rapidly, and adapt to cellular stress to maximize cell survival. The cellular stress response, also called (ISR), is universally conserved and independent of the stressor. ISR induces rapid, transient reprogramming of cellular protein translation

• br Conclusion br Introduction br CRL E ligases in tumorigene

  2020-12-30

  

  Conclusion Introduction CRL4 E3 ligases in tumorigenesis Small molecule-based PROTACs PROTAC: Major biological impacts Acknowledgements The authors sincerely apologize to all those colleagues whose important work was not cited in this paper owing to space limitations. They thank th

• External factors such as protein

  2020-12-30

  

  External factors, such as protein partners, can also activate DUBs by either reinforcing the stimulatory effects of intramolecular factors or by other means. The intramolecular activation of the USP7 CD by its HUBL domain is allosterically potentiated by external factor GMP synthase (GMPS), which co

• fak inhibitor br Methods br Results br Discussion Skin biops

  2020-12-30

  

  Methods Results Discussion Skin biopsy and microneurography have both been described as useful tools in the diagnosis of PAN, directly identifying peripheral sympathetic fibers without the mediation of specific fak inhibitor organs (Donadio et al., 2005, Donadio et al., 2012a, Donadio and L

• Because stimulation and blockade of

  2020-12-30

  

  Because stimulation and blockade of dopamine D2 receptor all cause a similar disruption of maternal behavior, one critical question is whether they do so through the same or different behavioral mechanisms. One idea is that stimulation or blockade of D2 receptors similarly suppresses maternal motiva

• Although high concentrations of SCR G and SCR R

  2020-12-30

  

  Although high concentrations of SCR7-G and SCR7-R inhibited LigIV as reported [11], the SCR7 derivatives were more effective inhibitors of LigIIIα and, in particular, LigI. Although it is possible that differences in the DNA substrate underlie this discrepancy, it appears more likely that this refle

• Furthermore we found that expression of two C nodule cystein

  2020-12-30

  

  Furthermore we found that expression of two C1 nodule cysteine proteases, Glyma.06G283100 and Glyma.06G174800, changed very little under drought despite the two proteases having similarity to the Arabidopsis senescence-related SAG12 gene with 62% similarity by Glyma.06G283010 and 58% by Glyma.06G174

• Preparation of the pyridyl ether analogs

  2020-12-30

  

  Preparation of the 2-pyridyl ether analogs (–) was accomplished by alkylation of alcohol with 2-bromopyridines in the presence of NaH to afford the desired pyridyl ether analogs in low to moderate yield. Preparation of the 3-pyridyl analog was carried out by conversion of alcohol to the tosylate, fo

• br Results and discussion br

  2020-12-30

  

  Results and discussion Conclusion In this research, several anti-inflammatory agents with pyrazolo[3,4-d]pyrimidine cores were synthesized. Such choice of large core than regular pyrazole was valid as a proper modification. That most of the prepared compounds showed excellent AI activity. In a

• Sarpogrelate hydrochloride So what can we glean from

  2020-12-30

  

  So what can we glean from this illuminative foray into how Chk1 and MK2 participate in checkpoint control? First and foremost, this work reveals that Sarpogrelate hydrochloride deficient in the tumor suppressor p53 contain two spatially distinct G2/M phase checkpoint control kinase networks. This p

• We hypothesize that both IGF dependent kinase

  2020-12-30

  

  We hypothesize that both IGF-1-dependent kinase activation and locally synthesized neuroestrogens interactively regulate estrogen receptor activity in neuronal IC261 mg in the absence of exogenously applied estradiol. The Neuro-2A cell line was chosen as the model system for these studies because I

• Nevertheless because of the preclinical

  2020-12-30

  

  Nevertheless, because of the preclinical work and the interference with EWS–FLI1 transcriptional activity, we believe that there may be a role for ET-743 in Ewing sarcoma. An analysis of the pharmacokinetic data published in the phase II clinical trial shows that at most the drug spent 5 to 6days ou

• br Materials and methods br Results br Discussion Our

  2020-12-30

  

  Materials and methods Results Discussion Our previous study showed that ERRγ negatively regulates osteoblast differentiation via inhibiting Runx2 transactivity (Jeong et al., 2009). In the present study, we found that ERRγ also induced miR-433 in osteogenic mesenchymal cell lineage C3H10T1/

• br EphB as a therapeutic target in cancer Eph receptors

  2020-12-30

  

  EphB4 as a therapeutic target in cancer Eph receptors and ephrins are promising new therapeutic targets in cancer. Various strategies have been employed to evaluate the interference of tumor-promoting effects or the enhancement of tumor suppressive effects. The inhibition of the Eph-ephrin system

15552 records 719/1037 page Previous Next First page 上5页 716717718719720 下5页 Last page