• The tumor suppressor function of LOX in normal prostate epit

  2024-10-12

  

  The tumor-suppressor function of 15-LOX-2 in normal prostate epithelial cells may be explained by the induction of replicative senescence [14,15]. Thus, 15-LOX-2 is overexpressed in age-dependent prostatic hyperplasia, but cell senescence may hinder progression to malignant transformation. Notwithst

• The transcription factor activator protein

  2024-10-12

  

  The transcription factor activator protein-1 (AP-1) is a redox-sensitive transcription factor whose activity is controlled by agents that perturb intracellular thiol concentrations [10,11]. AP-1 is mainly composed of Jun, Fos, and ATF protein dimers [12,13]. AP-1 mediates the regulation of numerous

• br Genetic analysis of polarity complexes Model organisms su

  2024-10-12

  

  Genetic analysis of polarity complexes Model organisms such as Caenorhabditis elegans and Drosophila melanogaster provide useful means of describing basic biological processes. They lend themselves particularly well to addressing some of the questions arising in this field because of their struct

• br Summary br Introduction With readily synthetic methods an

  2024-10-12

  

  Summary Introduction With readily synthetic methods and excellent chemical/physical characteristics, coumarins have received extensive attention and show great practical values in many fields, such as medicine discovery, dye chemistry, materials chemistry and so on [[1], [2], [3]]. Actually, o

• br Methodology br Antibiotics in

  2024-10-12

  

  Methodology Antibiotics in lakes Antibiotic resistance genes in lakes Perspectives of study on Malonic acid and ARGs in lakes Conclusion This paper systematically reviewed the distribution of antibiotics and ARGs in global lakes. A total of 57 antibiotics reported at least once in th

• Hyperactivity of the hypothalamus pituitary adrenal HPA

  2024-10-11

  

  Hyperactivity of the hypothalamus-pituitary-adrenal (HPA) axis, which is well described in MDD (Pariante and Lightman, 2008, Marques et al., 2009), is also observed in AD and results in increased glucocorticoid (GC, cortisol in primates) levels in blood and CSF (Davis et al., 1986, Martignoni et al.

• Glu Gln Asp and Asn the

  2024-10-11

  

  Glu, Gln, Asp, and Asn, the main Preladenant presented in the present study, are involved in nitrogen assimilation and transport processes within the plants. Furthermore, they are used to build up reserves during periods of nitrogen availability for subsequent use in growth, defense, and reproductiv

• When a clinician diagnoses a person with

  2024-10-11

  

  When a clinician diagnoses a person with AD, the person is transformed into a patient with the disease. The person is a member of a patient group associated with behaviors, abilities, and experiences related both formally and informally to the diagnosis [10]. The diagnostic label implies what signs

• br Disclosure br Acknowledgments br Introduction Deeper unde

  2024-10-11

  

  Disclosure Acknowledgments Introduction Deeper understanding of the pathobiology of non-small cell lung cancer (NSCLC) has led to the development of small SQ 29,548 that target genetic mutations known to play critical roles in the progression to metastatic disease. Mutations in epidermal g

• A rate limiting step in the

  2024-10-11

  

  A rate-limiting step in the generation of kynurenine and xanthurenic opioid receptor is the oxidation of N-formyl-kynurenine to l-kynurenine via indolamine 2,3-dioxygenase (IDO) or tryptophan dioxygenase (TDO). IDO and/or TDO knockdown decreases and ectopic over-expression increases production of e

• Notably both circulating adiponectin and adipsin were equall

  2024-10-11

  

  Notably, both circulating adiponectin and adipsin were equally diminished by about 50% in Arfrp1 mice consistent with several studies reporting overlapping trafficking routes for their secretion from 3T3-L1 WEHI-539 which was strikingly inhibited upon ablation of TfR-positive endosomes [18,26,33].

• Ethanol can affect biological systems directly or also throu

  2024-10-11

  

  Ethanol can affect biological systems directly, or also through the interactions between these systems, which become important in the actions promoted by alcohol consumption. Its metabolites acetaldehyde and acetate play a key role in the LY294002 mediating some effects of ethanol (Israel et al., 19

• The pathogenesis of d penicillamine induced MG

  2024-10-11

  

  The pathogenesis of d-penicillamine-induced MG is not clear. The repertoire of anti-AChR YM 58483 in d-penicillamine-induced MG has been shown to be similar to that in idiopathic MG in terms of AChR antigenic regions, suggesting a common immune mechanism (Tzartos et al., 1988). About 20% of d-peni

• From our in vivo studies and previously reported

  2024-10-11

  

  From our in vivo studies and previously reported findings [25], we have found that orteronel possesses excellent oral BA. Indeed, single oral dosing of orteronel at doses of 0.3–10.0mg/kg decreased serum DHEA levels in a dose-dependent manner. Of interest, DHEA levels did not return to levels compar

• br Materials and methods br

  2024-10-11

  

  Materials and methods Results Discussion We have developed a high-throughput functional genomic screen that allows the identification of genes that confer drug resistance. Several factors have been identified which must be taken into account to develop a reliable screen. In particular, cons

15588 records 74/1040 page Previous Next First page 上5页 7172737475 下5页 Last page